Cryptic crossword clue
O Simple eyes round small room — one follows 6

The most common and most likely answer to this crossword clue is the 6 letter word OCELLI

I've seen this crossword clue in The Guardian
O
C
E
L
L
I

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The straight part
We know that "Simple eyes" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case simple eyes = ocelli.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OCELLI mean?

OCELLI noun
  1. A simple eye consisting of a single lens and a small number of sensory cells.
  2. An eyelike marking in the form of a spot or ring of colour, as on the wing of a butterfly or the tail of a peacock.

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