The most common and most likely answer to this crossword clue is the 2 plus 4 plus 2 plus 5 letter word DA CAPO AL SEGNO
I've seen this crossword clue in The Guardian
D
A
C
A
P
O
A
L
S
E
G
N
O
Buddy explains!
The straight part
We know that "musical instruction" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case musical instruction = da capo al segno.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.