Cryptic crossword clue
Obama wrestling with problem requiring bit of guts 8

The most common and most likely answer to this crossword clue is the 8 letter word ABOMASUM

I've seen this crossword clue in The Guardian
A
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Buddy explains!

The straight part
We know that "bit of guts" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bit of guts = abomasum.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ABOMASUM mean?

ABOMASUM noun
  1. The fourth or digestive compartment of the stomach of a cow or other ruminant, after the omasum.

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