Cryptic crossword clue
Obese and without a roof over one’s head, ignoring inevitable conclusion is beyond comprehension 10

The most common and most likely answer to this crossword clue is the 10 letter word FATHOMLESS

F
A
T
H
O
M
L
E
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S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FATHOMLESS mean?

FATHOMLESS adjective
  1. Very deep (especially of water deeper than a lead line can measure); bottomless.
  2. (by extension) unfathomable or incomprehensible.

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