Cryptic crossword clue
Observe disheartened elders pray on vacation 4

The most common and most likely answer to this crossword clue is the 4 letter word ESPY

E
S
P
Y

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The straight part
We know that "Observe" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case observe = espy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ESPY mean?

ESPY verb
  1. To catch sight of; to see; to spot (said especially of something not easy to see)
  2. To examine and keep watch upon; to watch; to observe.
  3. To look or search narrowly; to look about; to watch; to take notice; to spy.

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