Cryptic crossword clue
Of a lens, misaligned between opposite points 4-5

The most common and most likely answer to this crossword clue is the 10 letter word WIDE-ANGLE

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Buddy explains!

The straight part
We know that "Of a lens" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case of a lens = wide-angle.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WIDE-ANGLE mean?

WIDE-ANGLE adjective
  1. Of or pertaining to a short focal length lens that has an angle of view greater than about 70°; of or pertaining to an image produced with such a lens.

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