The most common and most likely answer to this crossword clue is the 4 letter word NOPE
I've seen this crossword clue in Independent
N
O
P
E
More clues leading to the result NOPE
- Exercise cancelled? On the contrary
- Work in Northumberland? Emphatically not!
- Definitely not what inactive pupils want on timetable?
- Regularly in toupee? You must be joking
- I won't, casually, when opening curtains
- Frank, putting name forward, gets refusal ...
- Spread out cycling? Absolutely not
- Off games? Absolutely not!
- School activity cancelled? On the contrary
- Negative number making the class sweat
Buddy explains!

The straight part
We know that "Absolutely not!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case absolutely not! = nope.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does NOPE mean?
NOPE noun- A negative reply, no.
- An intensely undesirable thing, such as a circumstance or an animal, eliciting immediate repulsion without possibility of further consideration.
- (except near Staffordshire) A bullfinch
- A blow to the head.
- To hit someone on the head.