The most common and most likely answer to this crossword clue is the 12 letter word MANSLAUGHTER
I've seen this crossword clue in The Times
M
A
N
S
L
A
U
G
H
T
E
R
More clues leading to the result MANSLAUGHTER
- Servant's amusement causes serious offence
- One headless attack in case of mate at end of tether?
- Offence, and person’s inappropriate response?
- Crime - and chap's inappropriate reaction?
- Unladylike, this roaring? That could be the charge
- Bloke’s mirth is killing
- Possible conviction for killing someone’s amusement
- Charge for chap’s expression of amusement?
- Offence and fellow’s inappropriate response?
- Chap’s show of amusement is a grave offence
Buddy explains!

The straight part
We know that "Offence" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case offence = manslaughter.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MANSLAUGHTER mean?
MANSLAUGHTER noun- The slaying of a human being.
- The unlawful killing of a human, either in negligence or incidentally to the commission of some unlawful act, but without specific malice, or upon a sudden excitement of anger.