Cryptic crossword clue
Offend American spy, call him an old woman 7

The most common and most likely answer to this crossword clue is the 7 letter word FUSSPOT

F
U
S
S
P
O
T


Buddy explains!

The straight part
We know that "call him an old woman" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case call him an old woman = fusspot.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FUSSPOT mean?

FUSSPOT noun
  1. A person who makes a fuss, particularly about trivial things.

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