Cryptic crossword clue
Offend if caught between both sexes 4

The most common and most likely answer to this crossword clue is the 4 letter word MIFF

I've seen this crossword clue in The Daily Telegraph
M
I
F
F

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The straight part
We know that "Offend" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case offend = miff.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MIFF mean?

MIFF noun
  1. A small argument; a quarrel.
  2. A state of being offended.
MIFF verb
  1. (usually used in the passive) To offend slightly.
  2. To become slightly offended.

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