The most common and most likely answer to this crossword clue is the 10 letter word DEPARTMENT
I've seen this crossword clue in The Times
D
E
P
A
R
T
M
E
N
T
More clues leading to the result DEPARTMENT
- Office staff on leave before end of August
- Debussy's opening with E flat, cutting a section
- Leave chaps on time in area of France
- Ardent temp working in part of the firm
- Leave fellows needing time in division of company
- Leave time to include guys in office
- Leave valets at end of bureau
- Go with fellows and start to toil in field
- Go with guys foremost in the field
- Detach case of machine in hollow unit
Buddy explains!

The straight part
We know that "Office" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case office = department.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DEPARTMENT mean?
DEPARTMENT noun- A part, portion, or subdivision.
- A distinct course of life, action, study, or the like.
- A subdivision of an organization.
- A territorial division; a district; especially, in France, one of the districts into which the country is divided for governmental purposes, similar to a county in the UK and in the USA. France is composed of 101 départements organized in 18 régions, each department is divided into arrondissements, in turn divided into cantons.
- A military subdivision of a country
- Act of departing; departure.