The most common and most likely answer to this crossword clue is the 8 letter word CHOLERIC
I've seen this crossword clue in The Guardian
C
H
O
L
E
R
I
C
More clues leading to the result CHOLERIC
- Irritable clergyman touring Ohio regularly
- Angry minister without house
- Inclined to be cross about un-American show containing gap
- Oh, to be back in New Circle Cross
- Angry when a small quantity of her oil dripped in
- Bad tempered cleric captures head office
- Passionate minister enthrals house
- ‘Uptight‘ or Chic, ‘Le Freak’?
Buddy explains!

The straight part
We know that "Cross" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cross = choleric.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CHOLERIC mean?
CHOLERIC noun- A person with a choleric temperament.
- A person suffering from cholera (infectious disease).
- (according to theories of the four humours or temperaments) Having a temperament characterized by an excess of choler; easily becoming angry.
- Showing or expressing anger.
- Of or relating to cholera (infectious disease).
- Causing an excess of choler.