The most common and most likely answer to this crossword clue is the 6 letter word ORISON
I've seen this crossword clue in Financial Times
O
R
I
S
O
N
More clues leading to the result ORISON
- Saint included in hunter’s prayer
- Prayer old teacher offered up before broadcasting
- Prayer for one relative
- Group of stars penning intro to Save a Prayer
- Old jail with priest brought out for prayer
- Prayer for star eclipsing sun
- Prayer shawl initially bagged by hunter
- Confiteor is one’s prayer
- Prayer of saint to be set among the stars
- 8s’ Mary’s lost head in prayer
Buddy explains!

The straight part
We know that "prayer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case prayer = orison.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ORISON mean?
ORISON noun- A prayer.
- Mystical contemplation or communion.