Cryptic crossword clue
Old leper left H[AVILAND], Arizona essentially wary 5

The most common and most likely answer to this crossword clue is the 5 letter word LAZAR

L
A
Z
A
R

Buddy explains!

The straight part
We know that "Old leper" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case old leper = lazar.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LAZAR mean?

LAZAR noun
  1. A sufferer of an infectious disease, especially leprosy.

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