The most common and most likely answer to this crossword clue is the 7 letter word PAISANO
I've seen this crossword clue in The Times
P
A
I
S
A
N
O
More clues leading to the result PAISANO
Buddy explains!

The straight part
We know that "friend" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case friend = paisano.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PAISANO mean?
PAISANO noun- (Alternate spelling of paesano, from Neapolitan language "paisano," often shortened to "paisan" or "paesan") among Italian Americans and Americans of Italian descent, a fellow Italian or Italian-American; a fellow ethnic Italian.
- A native, especially a native of California of mixed Spanish and Indian ancestry.
- Roadrunner.