Cryptic crossword clue
Old man is missing by centre 3

The most common and most likely answer to this crossword clue is the 3 letter word HUB

I've seen this crossword clue in The Daily Telegraph
H
U
B


Buddy explains!

The straight part
We know that "centre" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case centre = hub.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HUB mean?

HUB noun
  1. The central part, usually cylindrical, of a wheel; the nave.
  2. A point where many routes meet and traffic is distributed, dispensed or diverted.
  3. A central facility providing a range of related services, such as a medical hub or an educational hub
  4. A computer networking device connecting several Ethernet ports. See switch.
  5. A stake with a nail in it, used to mark a temporary point.
  6. A male weasel; a buck; a dog; a jack.
  7. The hilt of a weapon.
  8. A rough protuberance or projecting obstruction.
  9. An area in a video game from which most or all of the game's levels are accessed.
  10. A goal or mark at which quoits, etc., are thrown.
  11. A hardened, engraved steel punch for impressing a device upon a die, used in coining, etc.
  12. A screw hob.
  13. A block for scotching a wheel.

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