Cryptic crossword clue
Old mother’s filling a hobo’s stomach 8

The most common and most likely answer to this crossword clue is the 8 letter word ABOMASUM

A
B
O
M
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M

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does ABOMASUM mean?

ABOMASUM noun
  1. The fourth or digestive compartment of the stomach of a cow or other ruminant, after the omasum.

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