The most common and most likely answer to this crossword clue is the 8 letter word OFTTIMES
I've seen this crossword clue in The Times
O
F
T
T
I
M
E
S
Buddy explains!
The straight part
We know that "in many cases" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in many cases = ofttimes.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does OFTTIMES mean?
OFTTIMES adverb- Often; frequently