The most common and most likely answer to this crossword clue is the 6 letter word CAVITY
I've seen this crossword clue in Independent
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CAVITY mean?
CAVITY noun- A hole or hollow depression.
- A hollow area within the body (such as the sinuses).
- A small or large hole in a tooth caused by caries; often also a soft area adjacent to the hole also affected by caries.