Cryptic crossword clue
On purpose, irritate people ahead of time, being put at risk 12

The most common and most likely answer to this crossword clue is the 12 letter word ENDANGERMENT

I've seen this crossword clue in The Sunday Telegraph
E
N
D
A
N
G
E
R
M
E
N
T

Buddy explains!

The straight part
We know that "put at risk" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case put at risk = endangerment.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENDANGERMENT mean?

ENDANGERMENT noun
  1. The act of putting someone into danger, or the condition of being in danger.
  2. The exposure of someone, especially a child, to danger or harm.

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