The most common and most likely answer to this crossword clue is the 10 letter word ANTAGONISE
I've seen this crossword clue in The Daily Telegraph
A
N
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A
G
O
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More clues leading to the result ANTAGONISE
- Arouse hostility against one deviously
- A new label is secured by a single needle
- Arouse hostility against one incorrectly
- Cause opposition to turn against one
- Could be one against change
- A son eating badly generates anger
- Turning one against needle
- Bug with a giant nose twitching
- Crazily go insane at seeing needle
- Social worker dealt with worry and anger
Buddy explains!
The straight part
We know that "needle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case needle = antagonise.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ANTAGONISE mean?
ANTAGONISE verb- To work against; to oppose (especially to incite reaction)