Cryptic crossword clue
Once at sea, I was off course by miles 5

The most common and most likely answer to this crossword clue is the 5 letter word ASWIM

A
S
W
I
M


Buddy explains!

The straight part
We know that "Once at sea" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case once at sea = aswim.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ASWIM mean?

ASWIM adjective
  1. Swimming or immersed (in or with something).
  2. Brimming with liquid.

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