The most common and most likely answer to this crossword clue is the 4 letter word AYES
I've seen this crossword clue in The Guardian
A
Y
E
S
More clues leading to the result AYES
- Heard detectives giving expressions of approval
- One or more positive responses viewers stated
- One agreement or many?
- A positive response? More than one!
- One vote in favour, or a number
- Votes for studies to be read out
- One positive response, or more than one
- Affirmations, or just one?
- Those in favour will give a positive response
- A word of approval for those in favour
Buddy explains!

The straight part
We know that "many" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case many = ayes.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does AYES mean?
AYES noun- An affirmative vote; one who votes in the affirmative.