Cryptic crossword clue
One appeal about drink that may be radioactive

The most common and most likely answer to this crossword clue is the 8 letter word ISOTOPES

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "that may be radioactive" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case that may be radioactive = isotopes.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ISOTOPES mean?

ISOTOPES noun
  1. Any of two or more forms of an element where the atoms have the same number of protons, but a different number of neutrons within their nuclei. As a consequence, atoms of isotopes will have the same atomic number but a different mass number.

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