Cryptic crossword clue
One caring for eyes unaccustomed to Soho lamplight 15

The most common and most likely answer to this crossword clue is the 15 letter word OPHTHALMOLOGIST

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does OPHTHALMOLOGIST mean?

OPHTHALMOLOGIST noun
  1. A medical doctor specializing in the eye: deficiencies of vision requiring correction, and diseases. Compare optometrist.

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