Cryptic crossword clue
One doesn’t much care to be without it 10

The most common and most likely answer to this crossword clue is the 10 letter word ENTHUSIASM

I've seen this crossword clue in The Guardian
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENTHUSIASM mean?

ENTHUSIASM noun
  1. Possession by a god; divine inspiration or frenzy.
  2. Intensity of feeling; excited interest or eagerness.
  3. Something in which one is keenly interested.

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