Cryptic crossword clue
One fishing with net swallows his last protein constituent 6

The most common and most likely answer to this crossword clue is the 6 letter word SERINE

S
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E

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The cryptic/wordplay part
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What does SERINE mean?

SERINE noun
  1. A nonessential amino acid, CH2OH.CH(NH2)COOH, found in most animal proteins, especially silk.

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