Cryptic crossword clue
One Greek character in exam getting most irritable 8

The most common and most likely answer to this crossword clue is the 8 letter word ITCHIEST

I
T
C
H
I
E
S
T

Buddy explains!

The straight part
We know that "most irritable" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most irritable = itchiest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ITCHIEST mean?

ITCHIEST adjective
  1. Having or creating an itch, causing a person or animal to tend to want to scratch.

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