Cryptic crossword clue
One Greek character in match least able to stand up straight? 8

The most common and most likely answer to this crossword clue is the 8 letter word TIPSIEST

I've seen this crossword clue in The Guardian
T
I
P
S
I
E
S
T

Buddy explains!

The straight part
We know that "east able to stand up straight" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case east able to stand up straight = tipsiest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TIPSIEST mean?

TIPSIEST adjective
  1. Slightly drunk, fuddled, staggering, foolish as a result of drinking alcoholic beverages
  2. (metonymy) unsteady, askew

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