Cryptic crossword clue
One hostile to Officer Commanding carry-on, say? 10

The most common and most likely answer to this crossword clue is the 10 letter word ICONOCLAST

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "One hostile to Officer Commanding carry-on, say" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one hostile to officer commanding carry-on, say = iconoclast.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ICONOCLAST mean?

ICONOCLAST noun
  1. One who destroys religious images or icons, especially an opponent of the Orthodox Church in the 8th and 9th centuries, or a Puritan during the European Reformation.
  2. One who opposes orthodoxy and religion; one who adheres to the doctrine of iconoclasm.
  3. (by extension) One who attacks cherished beliefs.

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