The most common and most likely answer to this crossword clue is the 10 letter word LONELINESS
I've seen this crossword clue in The Daily Telegraph
L
O
N
E
L
I
N
E
S
S
More clues leading to the result LONELINESS
- Isolation left sections without a piece of text
- Left single, poetry beginning to sharpen this?
- Isolation unit needed in outbreak of illness
- Solitude of drink — Venetian dismissing outsiders in bar …
- Exotic illness? One’s held in isolation
- One illness to suffer in isolation
- Alas, senile, no longer holding back solitude
- Penned in doggerel, one line’s spreading sad feelings
- 24 One in terrible illness and solitude
- Another illness overwhelms one in sad isolation
Buddy explains!
The straight part
We know that "in isolation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in isolation = loneliness.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LONELINESS mean?
LONELINESS noun- A feeling of depression resulting from being alone or from having no companions.
- The condition or state of being alone or having no companions.
- The state of being unfrequented or devoid of human activity (of a place or time).
- A desire to be alone; disposition to solitude.