The most common and most likely answer to this crossword clue is the 11 letter word HONEYMOONER
I've seen this crossword clue in The Times
H
O
N
E
Y
M
O
O
N
E
R
Buddy explains!
The straight part
We know that "One in hotel, say, finally free no more" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one in hotel, say, finally free no more = honeymooner.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.