Cryptic crossword clue
One in the eye ultimately for rude girl 6

The most common and most likely answer to this crossword clue is the 6 letter word RETINA

R
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A


Buddy explains!

The straight part
We know that "One in the eye" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one in the eye = retina.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RETINA mean?

RETINA noun
  1. The thin layer of cells at the back of the eyeball where light is converted into neural signals sent to the brain.

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