Cryptic crossword clue
One irritated by study and run down

The most common and most likely answer to this crossword clue is the 10 letter word DENIGRATED

I've seen this crossword clue in The Times
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The straight part
We know that "run down" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case run down = denigrated.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DENIGRATED mean?

DENIGRATED verb
  1. To criticise so as to besmirch; traduce, disparage or defame.
  2. To treat as worthless; belittle, degrade or disparage.
  3. To blacken.

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