Cryptic crossword clue
One key state American devastated to relax 4,2,4

The most common and most likely answer to this crossword clue is the 4 plus 2 plus 4 letter word TAKE IT EASY

I've seen this crossword clue in Financial Times
T
A
K
E
I
T
E
A
S
Y

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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