Cryptic crossword clue
One most hated female in church bites into host 4-5

The most common and most likely answer to this crossword clue is the 10 letter word ARCH-ENEMY

I've seen this crossword clue in The Guardian
A
R
C
H
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E
N
E
M
Y

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ARCH-ENEMY mean?

ARCH-ENEMY noun
  1. A principal enemy.
  2. A supreme and most powerful enemy.

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