Cryptic crossword clue
One objecting to 50% reduction in proper sample

The most common and most likely answer to this crossword clue is the 9 letter word PROTESTER

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "One objecting" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one objecting = protester.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PROTESTER mean?

PROTESTER noun
  1. One who protests, either singly or in a public display of group feeling.
  2. One who protests a bill of exchange, or note.

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