The most common and most likely answer to this crossword clue is the 7 letter word GHERKIN
I've seen this crossword clue in The Guardian
G
H
E
R
K
I
N
More clues leading to the result GHERKIN
- Bit of food and drink — kilo the female's put on must be hidden
- This woman ruler’s ending up in a pickle
- Last of strong female relatives in a pickle
- One of 4’s in a pickle?
- That lady’s man ending up in a pickle in 1/18D
- One getting in a pickle from using her Kindle
- Good family will take her to find London landmark
- That woman in good family that’s often pickled
- Contribution to helping her kinsman in a bit of a pickle
- Cucumber grown originally by that woman’s family
Buddy explains!

The straight part
We know that "One of 4’s/in a pickle?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one of 4’s/in a pickle? = gherkin.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GHERKIN mean?
GHERKIN noun- A small cucumber, often pickled whole.
- The penis.