The most common and most likely answer to this crossword clue is the 6 letter word TAIPAN
I've seen this crossword clue in The Daily Telegraph
T
A
I
P
A
N
Buddy explains!

The straight part
We know that "snake" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case snake = taipan.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TAIPAN mean?
TAIPAN noun- A foreign businessman in China; a tycoon.
- Any venomous elapid snake of the genus Oxyuranus, found in Australia and New Guinea.