Cryptic crossword clue
One on hand, if learning is disrupted 10

The most common and most likely answer to this crossword clue is the 10 letter word FINGERNAIL

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "One on hand" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one on hand = fingernail.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FINGERNAIL mean?

FINGERNAIL noun
  1. The hard, flat translucent covering near the tip of a human finger, useful for scratching and fine manipulation.

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