Cryptic crossword clue
One ousting fifty in Anglo-Zulu fighting, English struggle 7

The most common and most likely answer to this crossword clue is the 7 letter word AGONIZE

A
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The straight part
We know that "struggle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case struggle = agonize.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AGONIZE mean?

AGONIZE verb
  1. To writhe with agony; to suffer violent anguish.
  2. To struggle; to wrestle; to strive desperately, whether mentally or physically.

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