Cryptic crossword clue
One overlooked Rennaissance painter, a very important person 5

The most common and most likely answer to this crossword clue is the 5 letter word TITAN

I've seen this crossword clue in Financial Times
T
I
T
A
N


Buddy explains!

The straight part
We know that "very important person" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case very important person = titan.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TITAN mean?

TITAN noun
  1. Something or someone of very large stature, greatness, or godliness.

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