Cryptic crossword clue
One physics lecturer relaxed, not having caught the pox 8

The most common and most likely answer to this crossword clue is the 8 letter word SYPHILIS

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does SYPHILIS mean?

SYPHILIS noun
  1. A disease spread via sexual activity, caused by the bacterium Treponema pallidum.

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