Cryptic crossword clue
One picked on numbers of Romans around mouth of Tiber 6

The most common and most likely answer to this crossword clue is the 6 letter word VICTIM

I've seen this crossword clue in The Times
V
I
C
T
I
M


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The straight part
We know that "One picked on" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one picked on = victim.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VICTIM mean?

VICTIM noun
  1. One that is harmed—killed, injured, subjected to oppression, deceived, or otherwise adversely affected—by someone or something, especially another person or event, force, or condition; in particular:
  2. A living being which is slain and offered as a sacrifice, usually in a religious rite.

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