Cryptic crossword clue
One preserves profound work of art, we’re told 4-6

The most common and most likely answer to this crossword clue is the 4 plus 6 letter word DEEP FREEZE

I've seen this crossword clue in Financial Times
D
E
E
P
F
R
E
E
Z
E

Buddy explains!

The straight part
We know that "One preserves" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one preserves = deep freeze.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DEEP FREEZE mean?

DEEP FREEZE noun
  1. A freezer
DEEP FREEZE verb
  1. To freeze at very low temperatures.

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