Cryptic crossword clue
One rambling old US leader appears in 60 Minutes 5

The most common and most likely answer to this crossword clue is the 5 letter word HIKER

I've seen this crossword clue in The Guardian
H
I
K
E
R


Buddy explains!

The straight part
We know that "One ramblin/g" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one ramblin/g = hiker.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HIKER mean?

HIKER noun
  1. One who hikes, especially frequently.

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