Cryptic crossword clue
One refuses any different speaker 8

The most common and most likely answer to this crossword clue is the 8 letter word NAYSAYER

I've seen this crossword clue in The Daily Telegraph
N
A
Y
S
A
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R


Buddy explains!

The straight part
We know that "One refuses" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one refuses = naysayer.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NAYSAYER mean?

NAYSAYER noun
  1. One who consistently denies, criticizes, or doubts; a detractor.

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