Cryptic crossword clue
One seeking agreement riot made mad 8

The most common and most likely answer to this crossword clue is the 8 letter word MEDIATOR

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Buddy explains!

The straight part
We know that "One seeking agreement" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one seeking agreement = mediator.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MEDIATOR mean?

MEDIATOR noun
  1. One who negotiates between parties seeking mutual agreement.
  2. A chemical substance transmitting information to a targeted cell.

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