Cryptic crossword clue
One spotted crossing road asleep so needing treatment 10

The most common and most likely answer to this crossword clue is the 10 letter word LEOPARDESS

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "One spotted" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one spotted = leopardess.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LEOPARDESS mean?

LEOPARDESS noun
  1. A female leopard.

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