Cryptic crossword clue
One taking up course extremely eager after stupid delay 4,6

The most common and most likely answer to this crossword clue is the 4 plus 6 letter word DUMB WAITER

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "One taking up course" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one taking up course = dumb waiter.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DUMB WAITER mean?

DUMB WAITER noun
  1. A small elevator used to move food etc. from one floor of a building to another.
  2. A table or set of trays on rollers used for serving food.
  3. A lazy Susan.

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